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THC and CBD in the treatment of spasticity associated with multiple sclerosis
People with multiple sclerosis may have various symptoms during the development of the disease, among others: spasticity - can have a significant impact on well-being and quality of life. Control of symptoms, including spasticity, remains a key point of the strategy to improve health. Available drug therapies for spasticity sometimes have limited benefits and are often associated with poor tolerance. The results of the study report that when using drugs with CBD, we are dealing with a decrease in the severity of symptoms and with an improvement in health.
Cannabidiol has strong anti-inflammatory and immunosuppressive properties. In an experimental model of MS (using a virus), CBD reduces the transmigration of blood leukocytes by lowering the expression of the molecule vascular adhesion-1 (VCAM-1), chemokines (CCL2 and CCL5) and the proinflammatory cytokine IL-1β. ALSO, CBD is involved in suppressing microglial activation. In addition, the administration of CBD oils during a viral infection has a long-lasting positive effect on the body.
Sativex for the treatment of spasticity, pain and urinary tract ailments due to multiple sclerosis
Experimental and clinical data indicate the beneficial therapeutic effects of cannabis-based drugs for multiple sclerosis (MS). Cannabinoids have shown high clinical efficacy in the treatment of spasticity, neuropathic pain, and bladder dysfunction.
Analysis of cannabis-based treatments in neuropathic pain and multiple sclerosis
Summary of the efficacy and safety of cannabinoid-based drugs for neuropathic pain.