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A team of researchers from the University of California, San Francisco, published a study in The Journal of Neuroscience in which they focused on the endocannabinoid system and its role in preventing migraines. According to the research, activating cannabinoid receptors in the brain may help modulate pain signals. Knowing that cannabinoids are associated with the perception of neuropathic pain, the researchers wanted to see if they could have a similar effect in the treatment of migraine, which is primarily characterized by a throbbing and unrelenting headache.
A group of scientists studied gray matter peri-water supply (this is the part of the brain that is responsible for suppressing pain). The activity of pain receptors and nerve fibers associated with continuous headaches was mainly measured.
A-delta fibers are nerves that respond to cold, pressure and acute pain. According to the abstract of a scientific publication, activation of the CB1 receptor reduces the amount of delta fibers by more than 19%.
Another piece of evidence that the CB1 receptor can induce relief from migraine was the researchers' discovery that inhibition of the cannabinoid receptor prevented delta fiber pressure from dropping. However, the researchers emphasize that the mechanism that underlies migraine is quite complicated.
Triptans are a group of drugs used temporarily to relieve migraine-related pains and possibly affect serotonin receptors. However, a group of researchers confirmed that the underlying mechanism for relieving migraines may include interactions between cannabinoid and serotonin receptors in certain areas of the brain. Therefore, the authors emphasize that the resolution of pain associated with triptans may be related to the endocannabinoid system.
Source of medycznamarihuana.com