Can CBD be combined with other drugs?

CBD or cannabidiol may be an inhibitor of the metabolism of many drugs, because it can inhibit important classes of liver enzymes, i.e. cytochrome P450.

This causes an increase in the concentration of drugs in the blood. CBD may inhibit the metabolism of drugs associated m.in cyp2C19, which include:

- antidepressants (including SSRIs – citalopram, tricyclic drugs – amitriptyline, clomipramine, imipramine and moclobemide, bupropion)
- antiepileptic drugs (m.in benzodiazepines, phenobarbital, phenytoin)
- proton pump inhibitors, used to treat gastroesophageal reflux, stomach ulcers and heartburn
- antiplatelet agents (clopidogrel)
- beta-blockers (propranolol)
- others (antimalarial drugs, indomethacin, warfarin, gliclazide, some antiviral drugs).

CBD can also inhibit cytochrome P450 class 3A, including CYP 3A4, and CYP 3A5.

Their substrates are antihistamines (used in allergies), antibiotics (erythromycin, clarithromycin), antiviral drugs (e.g. ritonavir), immunomodulatory drugs (cyclosporine, sirolimus, tacrolimus), antiarrhythmics, steroids, contraceptives (progesterone).

They also affect the concentration of some anticancer drugs (docetaxel, glivec, irinotecan, paclitaxel, vincristine and others).

Effects of CBD on Drugs

It is not known whether the possible interactions are clinically significant, i.e. whether the increase in concentration may be harmful to our body and whether it affects the effectiveness of other drugs and CBD.

Nevertheless, you should always be careful when introducing various herbs, dietary supplements or CBD.