Hemp vs. Cannabis, CBD & CBDA

What's the difference?

Cannabis plants were used in ancient Asian villages more than 10,000 years ago, making them one of the first crops in human history. Both plants are hemp (Cannabis), however, 'hemp' or 'industrial hemp' is a term commonly used for cannabis strains that contain very low levels of tetrahydrocannabinol (THC) and are used for fibers and seeds.

What molecules does hemp contain?

The hemp plant contains more than 480 natural ingredients. The molecules that have received the most attention lately are cannabinoids. At least 85 different cannabinoids have been isolated from the cannabis plant. Nevertheless, there are also other molecules there: terpenes, chlorophyll, alkanes, nitrogenous compounds, amino acids, sugars, aldehydes, alcohols, ketones, flavonoids, glycosides, vitamins, pigments.

What makes cannabinoids so interesting?

Our body produces substances similar to cannabinoids, which we call endogenous cannabinoids or endocannabinoids. Plants produce similar cannabinoids, which we refer to as phytocannabinoids.

A few words about CBD & CBDa

CBD

Cannabis contains many different cannabinoids. We know of more than 80 types,

However, it seems that there are many more. Most of us have heard of a cannabinoid known as THC, a component of marijuana that you can get "high" after consuming. Unlike THC, CBD is a non-psychoactive cannabinoid and doesn't make you feel "high." CBD has an antipsychotic effect, which means that it works quite the opposite of THC. Numerous studies show that CBD has a compensatory effect on the intoxicating effects caused by THC consumption, such as memory disorders and paranoia.

CBD

In nature, CBD and THC are mainly found in acid form: CBD as CBDa and THC as THCA. Cannabis plants actually contain very small amounts of CBD and THC. An important fact is that if we eat the plant in raw form, as nature planned, it will not cause psychoactive side effects as THC does not have a psychoactive effect. We would have to heat THC to turn it into THC. Oils containing various forms of CBD are proving to be more effective than CBD alone.

CBD - therapeutic areas

The endocannabinoid system (ECS) is an organism system discovered over the past decade and involved in many physiological processes. Cannabinoids, which regulate the homeostasis of the body, are constantly circulating in the systems in the organisms of humans and animals, affecting all physiological processes. The endocannabinoid system consists of CB1 and CB2 receptors that directly or indirectly bind to cannabinoids and phytocannabinoids. CB1 receptors are excitatory receptors that occur in the central nervous system, lungs, liver and kidneys. CB2 receptors regulate immune responses and are located in the immune and circulatory systems.

Endogenous compounds such as anandamide and arachidonylglycerol (2-AG) are produced by mammals from fats and bind directly to CB1 and CB2 receptors, acting as neurotransmitters for cannabinoids. Cannabidiol, a naturally occurring cannabinoid in humans and various animals that has no psychoactive effects, is also a phytocannabinoid extracted from industrial hemp plants.

While CBD does not bind directly to receptors, it does affect stress receptors such as Soat2 and Cyp27a1, which control the metabolism of sterols (i.e., cholesterol). CBD oil increases the amount of anandamide and other important lipids, thereby indirectly increasing the availability of circulating cannabinoids that bind to CB1 and CB2 receptors. Studies confirm that cannabidiol in the form of CBD oil has a therapeutic effect both separately and in combination with other substances. CBD obtained from legal industrial hemp contains less than 0.2% THC, making it non-psychoactive. In addition, CBD oil has antiemetic, anxiolytic, anti-cancer properties and acts as an immune inhibitor.

Clinical endocannabinoid deficiency (CEDC) is divided into three types associated with different disease processes and disorders. These are: genetic, acquired and idiopathic autoimmune. Many conditions are associated in part with clinical endocannabinoid deficiency, and CBD supplementation requires continuous monitoring to enable the most optimal results for the individual. Metabolic syndrome, obesity, insulin resistance and related conditions have spread over the past two decades, becoming a pandemic associated with endocannabinoid regulation disorders in people around the world.

Visceral adipose tissue is an indicator of inflammatory processes affecting the digestive system. Fat accumulation occurs when substances foreign to the human digestive system are consumed in a repetitive way, e.g. processed foods containing synthetic sugars. This can lead to dysfunction of endocannabinoid receptors and associated depletion of endocannabinoids, which in turn causes the overactive immune system to produce a rapid inflammatory response.

to increase the volume of adipose tissue in the abdominal area. In the presence of appropriate endocannabinoids, the reaction of the immune system is modified and there is no excessive inflammation.

However, because synthetic food substances block the production of endocannabinoids and thus alter the reactions of CB1 and CB2, an overactive immune response provokes excessive inflammation in the gastrointestinal tract and abdomen, causing them to enlarge. Such a phenomenon, when repeated daily, leads to the formation of metabolic syndrome and obesity, which is directly related to insulin resistance and leads to diabetes. In the light of the latest research on the role of the endocannabinoid system as a key center regulating systems in the human body and other mammals, education is necessary to prevent the occurrence of behaviors and change habits leading to metabolic dysregulation.

Exercise is the basis for the functioning of physiological systems in the human body, and countless studies clearly document their benefits. Nevertheless, the effects of exercising, even when combined with a reduced number of calories intake, do not go hand in hand with weight loss, and more importantly, with the loss of visceral fat. The endocannabinoid system requires the presence of appropriate cannabinoids to maintain metabolic balance and reduce visceral fat, associated with inflammation of the gastrointestinal tract. Since the consumption of phytocannabinoids, which effectively regulate the endocannabinoid system, is definitely insufficient in developed countries around the world, it is recommended to consume cannabidiol (CBD oil) as a food, combined with the elimination of synthetic foods, as a complementary option in combating obesity and related diseases. In a recent study, the Cannabinoid Research Group (Reillo, 2015) found a relationship between increased nitric oxide content in saliva and CBD intake.

The level of nitric oxides in the human body is associated with numerous cardiovascular functions, immunological, metabolic and neurological processes, and their depletion directly affects the dysfunction of endocannabinoids. Optimal levels of nitrogen oxides are associated with adequate phytocannabinoid uptake and a healthy endocannabinoid system.

Validation by measuring the effects of CBD on humans in the form of nitrogen oxide expression is an important tool for assessing a person's performance by a healthcare professional. In addition, it allows you to evaluate the quality of the CBD product recommended for consumption according to the guidelines of your healthcare professional.

CBD interacts with and modulates the endocannabinoid system, endogenous activators (ligands) in the human body, enzymes and their transporters. In addition, cannabinoids interact with other important neurotransmitter systems, along with TRP ion channels.

The effectiveness of CBD has been confirmed in various therapeutic areas. Important pharmacological effects include:

• anti-inflammatory effect
• increasing the absorption of medicines
• supporting biochemical processes affecting the fight against diabetes
• antipsychotic effect
• reduction of symptoms of anxiety and depression
• regulating obesity
• antiepileptic effect
• antitumor agent

Why is it worth taking advantage of our offer?

Do you really know what your hemp extract contains?

Unfortunately, most CBD extracts are produced without access to appropriate laboratory equipment, and many manufacturers use toxic solvents in the extraction process, the residues of which are later found in the product. In addition to chemical residues from the extraction process, many commercially available products contain toxins such as pesticides, heavy metals, herbicides, e-coli bacteria, mold, fungi and even mycotoxins that are dangerous to health.

So you may have stomach ailments, discover that CBD oil is not effective, or even poison yourself with carcinogens by using non-certified CBD oil that has been produced without properly applying yourself to the issue of quality.

The right plant is it

There are many ways to improve production and efficiency, and one of them is the use of chemical fertilizers and pesticides. We all know that such methods are not good for us, and we could even turn a blind eye to it when hemp is used to produce fibres, but when we are going to consume a product derived from such a cultivated plant or, more importantly, use it as a medicine, it is simply unacceptable. Such chemicals will be concentrated in oil extract, and when ingested they can even be fatal.

Fortunately, there are ethical companies like Endoca that have opted for an organic method of producing hemp oil and use the purest and most advanced extraction methods available today.

Should you choose synthetic CBD or natural?

How much CBD is in the bottle? This question seems simple, but in the absence of regulation, supplement manufacturers can print any fictitious information on the label of their product.

How do we know if we can trust a CBD manufacturer?

The most important points to pay attention to:

- Product batches are tested internally, but also by an independent

- third party, and the results of the tests are published

- Certificate of Good Manufacturing Practice (GMP)

- Certificate of the International Organization for Standardization

(ISO)

- Available customer service that can be easily contacted

Good Manufacturing Practices (GMP) are practices required to comply with the recommendations recommended by the authorities that control the authorization and licensing of the production and sale of food, medicinal products and active pharmaceuticals. These recommendations lay down minimum requirements that pharmaceutical and food manufacturers must respect in order to guarantee the high quality of the products offered and to ensure that they do not pose a risk to consumer and public health.

Ask your CBD oil manufacturer for your GMP certification number, if they have one!

Synthetic CBD

The production of synthetic CBD is simple and profitable. There is only one problem: it does not work! Such a product may seem similar in chemical composition, but it will not be as effective in treatment and may even be dangerous. Studies show that only CBD of fully plant origin is the only effective form of CBD.

How can I choose a good CBD oil?

Points that will help you navigate the CBD oil market:

The manufacturer is GMP certified

Batch test results are available

Transparent information is available on laboratory tests performed by independent operators

The manufacturer works "from seed to shelf" and maintains 100% control over the entire production process

Organic production methods are used

Other consumers trust the brand