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A growing body of data highlights the role of the endocannabinoid system in the stress response by influencing the hypothalamic-pituitary-adrenal axis and the control of reproduction by modifying gonadotropin release, fertility, and sexual behavior.
These results suggest that cannabinoids play a key role in maintaining hormonal homeostasis and that, despite the need for further research, CBD appears to be a promising therapy for the treatment of endocrine disorders.
Diabetes mellitus is an endocrine disorder with a strong hereditary component that children and adults suffer from throughout their lives. Diabetes mellitus develops insulin resistance and glucose dysregulation occurs, which significantly affects the circulatory, immune, nervous and endocrine systems through changes in micro- and macrovascular systems.
The evidence clearly indicates that the endocannabinoid system plays a key role in the development of primary diabetes and its numerous complications, proving that the hyperactive endocannabinoid system through the hyperactivity of CB1 receptors is associated with the formation of oxidative and nitration stress, inflammation, adipogenesis, lipogenesis, increased insulin resistance and increased appetite.
CBD, as a potent inhibitor of oxidative and nitrogen stress and inflammation, has been shown to be effective in the treatment of diabetes. Some mice with initial symptoms of diabetes were treated with CBD, while some did not.
In 32% of the group given CBD, the disease developed, while in the group in which CBD was not used, the disease developed 100%.
The ever-growing amount of scientific material confirms the benefits of CBD in lowering insulin resistance and acting in hypoglycemia.
Increasingly, CBD oil is recommended as a potential therapy for the treatment of diabetes.
CBD definitely seems to have preventive effects on insulin resistance and to act preventively before the development of full diabetes by administering it to healthy people at risk of diabetes, diabetic and diabetic patients.